Cyclopropylamine → HCID 178466944, compound

HRID 1297648Notes

Reaction equation

HRID 1297648 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:15]3/[C:16](=[O:22])[N:17]=[C:18](SC)[S:19]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:23]#[N:24])[CH3:2].[CH:25]1([NH2:28])[CH2:27][CH2:26]1.CCN(C(C)C)C(C)C>>[CH:25]1([NH:28][C:18]2[S:19]/[C:15](=[CH:14]\[C:11]3[CH:12]=[C:13]4[C:8](=[CH:9][CH:10]=3)[N:7]=[CH:6][C:5]([C:23]#[N:24])=[C:4]4[O:3][CH2:1][CH3:2])/[C:16](=[O:22])[N:17]=2)[CH2:27][CH2:26]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 585858204-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile

Product 1

HCID 178466944HCID 178466944, compound

Procedure

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), cyclopropylamine and DIEA to give 6-[2-Cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-ethoxy-quinoline-3-carbonitrile. LC-MS m/e 365 (MH+).

Sources & evidence

ORD record
ord-bf6abab4bb10446fa468845ed70018c0
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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