Diisopropylethylamine → HCID 178466949, compound

HRID 1297650Notes

Reaction equation

HRID 1297650 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:15]3/[C:16](=[O:22])[N:17]=[C:18](SC)[S:19]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:23]#[N:24])[CH3:2].[S:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH2:30][NH2:31].CCN(C(C)C)C(C)C>>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:15]3/[C:16](=[O:22])[N:17]=[C:18]([NH:31][CH2:30][C:26]4[S:25][CH:29]=[CH:28][N:27]=4)[S:19]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:23]#[N:24])[CH3:2]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27565071,3-Thiazol-2-ylmethanamineHCID 585858204-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile

Product 1

HCID 178466949HCID 178466949, compound

Procedure

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), thiazol-2-ylmethyl-amine and DIEA to give 4-ethoxy-6-[4-oxo-2-[(thiazol-2-ylmethyl)-amino]-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile. LC-MS m/e 422 (MH+).

Sources & evidence

ORD record
ord-ba9ca80af3bd4ab0a70821b01a573367
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…