HRID1297658

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID517045

Sodium Acetate

C2H3NaO2

结构：CC(C)(C)OC(=O)N1CCC(Oc2c(C#N)cnc3ccc(C=O)cc23)CC1

HCID58585840

未命名化合物

HCID178516935

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)N1CCC(Oc2c(C#N)cnc3ccc(/C=C4\SC(NC5CC5)=NC4=O)cc23)CC1$

HCID178452146

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Similar procedure as described in example 28c was used, starting from 4-(3-cyano-6-formyl-quinolin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (example 31b), 2-cyclopropylamino-thiazol-4-one, sodium acetate and acetic acid to give 4-{3-cyano-6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinolin-4-yloxy}-piperidine-1-carboxylic acid tert-butyl ester. LC-MS m/e 520 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ec74fb6fb0846759de427bc7b5e4ec8
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07250515B2
来源说明: uspto-grants-2007_07

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH:25]=O)[CH:23]=3)[N:18]=[CH:17][C:16]=2[C:27]#[N:28])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:29]1([NH:32][C:33]2[S:34][CH2:35][C:36](=[O:38])[N:37]=2)[CH2:31][CH2:30]1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22](/[CH:25]=[C:35]4/[C:36](=[O:38])[N:37]=[C:33]([NH:32][CH:29]5[CH2:31][CH2:30]5)[S:34]/4)[CH:23]=3)[N:18]=[CH:17][C:16]=2[C:27]#[N:28])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]