HRID1297659

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

$结构：CC(C)(C)OC(=O)N1CCC(Oc2c(C#N)cnc3ccc(/C=C4\SC(NC5CC5)=NC4=O)cc23)CC1$

HCID178452146

未命名化合物

PRODUCTS

生成物

结构：N#Cc1cnc2ccc(C=C3SC(NC4CC4)=NC3=O)cc2c1OC1CCNCC1

HCID178510292

未命名化合物

PROCEDURE

实验过程

Similar procedure as described in example 30 was used, starting from 4-{3-cyano-6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinolin-4-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (example 33) and 4N HCl/Dioxane to give 6-(2-cyclopropylamino-4-oxo-4H-thiazol-5-ylidenemethyl)-4-(piperidin-4-yloxy)-quinoline-3-carbonitrile; hydrochloride. LC-MS m/e 420 (MH+).