1,4-Dioxane hydrochloride → 6-[[2-(cyclopropylamino)-4-oxo-1,3-thiazol-5-ylidene]methyl]-4-piperidin-4-yloxyquinoline-3-carbonitrile

HRID 1297659Notes

Reaction equation

HRID 1297659 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22](/[CH:25]=[C:26]4/[C:27](=[O:35])[N:28]=[C:29]([NH:31][CH:32]5[CH2:34][CH2:33]5)[S:30]/4)[CH:23]=3)[N:18]=[CH:17][C:16]=2[C:36]#[N:37])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>>[CH:32]1([NH:31][C:29]2[S:30][C:26](=[CH:25][C:22]3[CH:23]=[C:24]4[C:19](=[CH:20][CH:21]=3)[N:18]=[CH:17][C:16]([C:36]#[N:37])=[C:15]4[O:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:27](=[O:35])[N:28]=2)[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178452146HCID 178452146, compound

Product 1

HCID 1785102926-[[2-(cyclopropylamino)-4-oxo-1,3-thiazol-5-ylidene]methyl]-4-piperidin-4-yloxyquinoline-3-carbonitrile

Procedure

Similar procedure as described in example 30 was used, starting from 4-{3-cyano-6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinolin-4-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (example 33) and 4N HCl/Dioxane to give 6-(2-cyclopropylamino-4-oxo-4H-thiazol-5-ylidenemethyl)-4-(piperidin-4-yloxy)-quinoline-3-carbonitrile; hydrochloride. LC-MS m/e 420 (MH+).

Sources & evidence

ORD record
ord-714d106d6ad5497691fe80ef4ca64de8
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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