HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 6-[[2-(cyclopropylamino)-4-oxo-1,3-thiazol-5-ylidene]methyl]-4-piperidin-4-yloxyquinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | HCID 178452146 | HCID 178452146 | — |
| Product | 6-[[2-(cyclopropylamino)-4-oxo-1,3-thiazol-5-ylidene]methyl]-4-piperidin-4-yloxyquinoline-3-carbonitrile | HCID 178510292 | — |
Reaction Steps
Similar procedure as described in example 30 was used, starting from 4-{3-cyano-6-[2-cyclopropylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinolin-4-yloxy}-piperidine-1-carboxylic acid tert-butyl ester (example 33) and 4N HCl/Dioxane to give 6-(2-cyclopropylamino-4-oxo-4H-thiazol-5-ylidenemethyl)-4-(piperidin-4-yloxy)-quinoline-3-carbonitrile; hydrochloride. LC-MS m/e 420 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250515B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-714d106d6ad5497691fe80ef4ca64de8 |
| Source note | uspto-grants-2007_07 |