Sodium Acetate → HCID 11669484, compound

HRID 1297666Notes

Reaction equation

HRID 1297666 reaction equation
C([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]2[O:15][CH:16]([C:21]([F:24])([F:23])[F:22])[C:17]([F:20])([F:19])[F:18])=O.COC1C=CC(/[CH:39]=[C:40]2/[C:41]([NH:43][C:44]([S:46]/2)=[NH:45])=[O:42])=CC=1OC1CCCC1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[NH2:45][C:44]1[S:46]/[C:40](=[CH:39]\[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][C:7]([C:13]#[N:14])=[C:6]3[O:15][CH:16]([C:17]([F:20])([F:18])[F:19])[C:21]([F:22])([F:23])[F:24])/[C:41](=[O:42])[N:43]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 58585856HCID 58585856, compoundHCID 137629131(5Z)-5-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one

Product 1

HCID 11669484HCID 11669484, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 38 was used, starting from 6-formyl-4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-quinoline-3-carbonitrile (example 45b), pseudothiohydantoin, sodium acetate and acetic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-quinoline-3-carbonitrile. LC-MS m/e 447 (MH+).

Sources & evidence

ORD record
ord-cdc580d2a0b54daf959bee681aa6bbf6
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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