Benzocaine → HCID 68826262, compound

HRID 1297668Notes

Reaction equation

HRID 1297668 reaction equation
[C:1]([C:3](=[CH:9]OCC)[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].[CH2:13]([O:15][C:16](=[O:24])[C:17]1[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:24])[C:17]1[CH:22]=[CH:21][C:20]([NH:23][CH:9]=[C:3]([C:1]#[N:2])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:19][CH:18]=1)[CH3:14]

Participants

3

Reactant 2

HCID 2337BenzocaineHCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester

Product 1

HCID 68826262HCID 68826262, compound

Conditions

Temperature
150 °C

Procedure

The mixture of ethyl 2-cyano-3-ethoxyacrylate (28.5 g, 0.168 mol) and 4-aminobenzoic acid ethyl ester (26.5 g, 0.16 mol) was heated at 150° C. for 2 h, detected by HPLC. After cooling to room temperature, the reaction mixture was dried under reduced pressure to give 4-(2-cyano-2-ethoxycarbonyl-vinylamino)-benzoic acid ethyl ester as a grey solid. LC-MS m/e 289 (MH+).

Workup

  1. temperatureAfter cooling to room temperature
  2. customthe reaction mixture was dried under reduced pressure

Sources & evidence

ORD record
ord-bf376c697fcd4541acc8b05a1a76e05a
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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