Diisopropylethylamine → HCID 58585824, compound

HRID 1297678Notes

Reaction equation

HRID 1297678 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]#[N:14].CCN(C(C)C)C(C)C.[SH:24][CH2:25][CH2:26][CH2:27][OH:28]>>[OH:28][CH2:27][CH2:26][CH2:25][S:24][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]#[N:14]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 882113-MercaptopropanolHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 58585824HCID 58585824, compound

Procedure

Similar procedure as described in example 39a was used, starting from 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c), DIEA and 3-mercapto-1-propanol to give 4-(3-hydroxy-propylsulfanyl)-6-iodo-quinoline-3-carbonitrile. LC-MS m/e 371 (MH+).

Sources & evidence

ORD record
ord-e67afc2ac675486884fa209e0ab0f4b8
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…