Ethanethiol → HCID 68825568, compound

HRID 1297686Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]#[N:14].[CH2:15]([SH:17])[CH3:16].CCN(C(C)C)C(C)C>>[CH2:15]([S:17][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]#[N:14])[CH3:16]

Participants

Reactant 3

HCID 6343Ethanethiol

HCID 81531Diisopropylethylamine

HCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 68825568HCID 68825568, compound

Procedure

Similar procedure as described in example 39a was used, starting from 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c), ethanethiol and DIEA to give 4-ethylsulfanyl-6-iodo-quinoline-3-carbonitrile. LC-MS m/e 341 (MH+).

Sources & evidence

ORD record: ord-66ab37b188934d8a88758ed10352c891
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250515B2

Reaction notes

Loading…