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HRID1297696

反应详情

EQUATION

反应方程式

HRID 1297696 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccccc1
HCID6115

Aniline

C6H7N

结构：CCOC=C(C(=O)OCC)S(C)(=O)=O
HCID71353473

Ethyl 3-ethoxy-2-(methanesulfonyl)prop-2-enoate

C8H14O5S

PRODUCTS

生成物

1
结构：CCOC(=O)C(=CNc1ccc(C(=O)OCC)cc1)S(C)(=O)=O
HCID68825474

未命名化合物

CONDITIONS

反应条件

温度
145 °C

PROCEDURE

实验过程

The compound of 3-ethoxy-2-methanesulfonyl-acrylic acid ethyl ester (example 61c, 52 g, 0.234 mol) and aniline (38.65 g, 0.234 mol) was mixed and heated at 140-150° C. under stirring for two hours. After cooling the reaction to room temperature, solvent was removed to give 4-(2-ethoxycarbonyl-2-methanesulfonyl-vinylamino)-benzoic acid ethyl ester. The crude compound was used in the following reaction without further purification. LC-MS m/e 342 (MH+).

WORKUP

后处理

  1. temperatureAfter cooling
  2. customthe reaction to room temperature
  3. customsolvent was removed