Ammonia → 2-Amino-5-[1-(3-methanesulfonyl-4-phenyl-quinolin-6-yl)-meth-(z)-ylidene]-thiazol-4-one

HRID 1297704Notes

Reaction equation

HRID 1297704 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([CH:21]=[C:22]1[S:26][C:25](SC)=[N:24][C:23]1=[O:29])=[CH:10][CH:9]=2)(=[O:4])=[O:3].[NH3:30]>CO>[NH2:30][C:25]1[S:26]/[C:22](=[CH:21]\[C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[C:14]3[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)/[C:23](=[O:29])[N:24]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 688250605-(3-Methanesulfonyl-4-phenyl-quinolin-6-ylmethylene)-2-methylsulfanyl-thiazol-4-one

Product 1

HCID 115316262-Amino-5-[1-(3-methanesulfonyl-4-phenyl-quinolin-6-yl)-meth-(z)-ylidene]-thiazol-4-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Similar procedure as described in example 41c was used, starting from 5-(3-methanesulfonyl-4-phenyl-quinolin-6-ylmethylene)-2-methylsulfanyl-thiazol-4-one (example 61k), and ammonia in methanol to give 2-amino-5-[1-(3-methanesulfonyl-4-phenyl-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 410 (MH+).

Sources & evidence

ORD record
ord-1481e6bcc1e3490284c5c30bd1c43155
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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