Methyl iodide → HCID 68824865, compound

HRID 1297714Notes

Reaction equation

HRID 1297714 reaction equation
[O:1]=[C:2]1[C:6](=[CH:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][C:12]([C:18]#[N:19])=[C:11]3[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[S:5][C:4](=[S:26])[NH:3]1.IC.[CH:29](N(C(C)C)CC)(C)C>C(#N)C>[CH3:29][S:26][C:4]1[S:5][C:6](=[CH:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][C:12]([C:18]#[N:19])=[C:11]3[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[C:2](=[O:1])[N:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 768238436-(4-Oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-4-pyridin-3-yl-quinoline-3-carbonitrile

Product 1

HCID 68824865HCID 68824865, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Similar procedure as described in example 41b was used, starting from 6-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-4-pyridin-3-yl-quinoline-3-carbonitrile (example 63d), iodomethane, and DIEA (diisopropylethylamine) in acetonitrile to give 6-(2-methylsulfanyl-4-oxo-4H-thiazol-5-ylidenemethyl)-4-pyridin-3-yl-quinoline-3-carbonitrile. LC-MS m/e 389 (MH+).

Sources & evidence

ORD record
ord-b9a2d72d0f4b4e839ca44ff5558e611a
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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