Hydrazine hydrate (1:1) → HCID 19370372, compound

HRID 129773Notes

Reaction equation

HRID 129773 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][N:23]2C(=O)C3=CC=CC=C3C2=O)[CH2:17][CH2:16]1)[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1.O.NN>>[NH2:23][CH2:22][CH2:21][N:18]1[CH2:17][CH2:16][N:15]([CH:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19370382HCID 19370382, compound

Product 1

HCID 19370372HCID 19370372, compoundYield 88%

Procedure

The title compound was prepared in a yield of 88% in a similar manner to that described in Preparation 15' by reacting 4-[α-(2-pyridyl)-4-fluorobenzyl]-1-(2-phthalimidoethyl)piperazine (prepared as described in Preparation 51') and hydrazine hydrate.

Workup

  1. customdescribed in Preparation 15'
  2. customprepared

Sources & evidence

ORD record
ord-60ca92ff587d456e9ec601ba0ee88810
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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