Water → HCID 58585848, compound

HRID 1297732Notes

Reaction equation

HRID 1297732 reaction equation
C(OC(=O)[CH:5]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[N:14]=[CH:13][C:12]=1[C:22]#[N:23])C(OCC)=O)C.[Cl-].[Li+].O>CS(C)=O>[I:21][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]=[CH:13][C:12]([C:22]#[N:23])=[C:11]2[CH3:5]

Participants

5

Reactant 3

HCID 962WaterHCID 433294Lithium ChlorideHCID 58585851HCID 58585851, compound

Product 1

HCID 58585848HCID 58585848, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Similar procedure as described in example 71b was used, starting 2-(3-cyano-6-iodo-quinolin-4-yl)-malonic acid diethyl ester (example 73a), lithium chloride, water, and dimethylsulfoxide to give 6-iodo-4-methyl-quinoline-3-carbonitrile. LC-MS m/e 295 (MH+).

Sources & evidence

ORD record
ord-37473fa5fe2c46139ad318560cf8a458
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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