Cyclopropylamine → HCID 178467343, compound

HRID 1297738Notes

Reaction equation

[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=[C:15]3[S:19][C:18](SCC)=[N:17][C:16]3=[O:23])[CH:12]=2)[N:7]=[CH:6][C:5]=1[S:24]([CH3:27])(=[O:26])=[O:25])[CH3:2].[CH:28]1([NH2:31])[CH2:30][CH2:29]1.C(N(C(C)C)CC)(C)C>>[CH:28]1([NH:31][C:18]2[S:19]/[C:15](=[CH:14]\[C:11]3[CH:12]=[C:13]4[C:8](=[CH:9][CH:10]=3)[N:7]=[CH:6][C:5]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:4]4[O:3][CH2:1][CH3:2])/[C:16](=[O:23])[N:17]=2)[CH2:30][CH2:29]1

Participants

Reactant 3

HCID 69828Cyclopropylamine

HCID 81531Diisopropylethylamine

HCID 68825957HCID 68825957, compound

Product 1

HCID 178467343HCID 178467343, compound

Procedure

Similar procedure as described in example 41c was used, starting from 5-(4-ethoxy-3-methanesulfonyl-quinolin-6-ylmethylene)-2-ethylsulfanyl-thiazol-4-one (example 74e), cyclopropylamine, and DIEA (diisopropylethylamine) to give 2-cyclopropylamino-5-[1-(4-ethoxy-3-methanesulfonyl-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 418 (MH+).

Sources & evidence

ORD record: ord-a70a212714ef49bba12da304c07ccaad
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250515B2

Reaction notes

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