Ammonia → HCID 11595977, compound

HRID 1297739Notes

Reaction equation

HRID 1297739 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=[C:15]3[S:19][C:18](SCC)=[N:17][C:16]3=[O:23])[CH:12]=2)[N:7]=[CH:6][C:5]=1[S:24]([CH3:27])(=[O:26])=[O:25])[CH3:2].N.C([N:32](C(C)C)CC)(C)C>CO>[NH2:32][C:18]1[S:19]/[C:15](=[CH:14]\[C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]=[CH:6][C:5]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:4]3[O:3][CH2:1][CH3:2])/[C:16](=[O:23])[N:17]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 81531DiisopropylethylamineHCID 68825957HCID 68825957, compound

Product 1

HCID 11595977HCID 11595977, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Similar procedure as described in example 41c was used, starting from 5-(4-ethoxy-3-methanesulfonyl-quinolin-6-ylmethylene)-2-ethylsulfanyl-thiazol-4-one (example 74e), ammonia in methanol, and DIEA (diisopropylethylamine) to give 2-amino-5-[1-(4-ethoxy-3-methanesulfonyl-quinolin-6-yl)-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 378 (MH+).

Sources & evidence

ORD record
ord-91226441ecb7486ebff3a2092898479d
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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