Hydrazine hydrate (1:1) → HCID 19370316, compound

HRID 129774Notes

Reaction equation

HRID 129774 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([N:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][N:26]2C(=O)C3=CC=CC=C3C2=O)[CH2:20][CH2:19]1)[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1.O.NN>>[NH2:26][CH2:25][CH2:24][N:21]1[CH2:22][CH2:23][N:18]([CH:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19370387HCID 19370387, compound

Product 1

HCID 19370316HCID 19370316, compound

Procedure

The title compound was prepared in a quantitative yield in a similar manner to that described in Preparation 15' by reacting 4-[α-(2-pyridyl)-4-trifluoromethylbenzyl]-1-(2-phthalimidoethyl)piperazine (prepared as described in Preparation 52') and hydrazine hydrate.

Workup

  1. customdescribed in Preparation 15'
  2. customprepared

Sources & evidence

ORD record
ord-c94746eebedd490f9a6c1dc0440cf5aa
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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