HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-4H-pyran-4-ol → HCID 68825367, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| Reactant | Potassium hydride | HCID 82127 | — |
| Reactant | 4-Chloro-6-iodoquinoline-3-carbonitrile | HCID 22466769 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68825367 | HCID 68825367 | — |
Reaction Steps
Similar procedure as described in example 28a was used, starting from 4-hydroxy tetrahydropyran, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 6-iodo-4-(tetrahydro-pyran-4-yloxy)-quinoline-3-carbonitrile. LC-MS m/e 381 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250515B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-9bd07f5308e2466780b2431cd87f537a |
| Source note | uspto-grants-2007_07 |