Tetrahydro-4H-pyran-4-ol → HCID 68825367, compound

HRID 1297740Notes

Reaction equation

HRID 1297740 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([I:19])[CH:17]=2)[N:12]=[CH:11][C:10]=1[C:20]#[N:21].[H-].[K+]>C1COCC1>[I:19][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][C:10]([C:20]#[N:21])=[C:9]2[O:1][CH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 74956Tetrahydro-4H-pyran-4-olHCID 82127Potassium hydrideHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 68825367HCID 68825367, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Similar procedure as described in example 28a was used, starting from 4-hydroxy tetrahydropyran, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 6-iodo-4-(tetrahydro-pyran-4-yloxy)-quinoline-3-carbonitrile. LC-MS m/e 381 (MH+).

Sources & evidence

ORD record
ord-9bd07f5308e2466780b2431cd87f537a
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…