Hydrazine hydrate (1:1) → HCID 19370321, compound

HRID 129776Notes

Reaction equation

HRID 129776 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[C:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][N:22]2C(=O)C3=CC=CC=C3C2=O)[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O.NN>>[NH2:22][CH2:21][CH2:20][CH2:19][N:16]1[CH2:17][CH2:18][C:13](=[C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19370259HCID 19370259, compound

Product 1

HCID 19370321HCID 19370321, compoundYield 92%

Procedure

The title compound was prepared in a yield of 92% in a similar manner to that described in Preparation 15' by reacting 4-[α-(2-thienyl)benzylidene]-1-(3-phthalimidopropyl) piperidine (prepared as described in Preparation 54') and hydrazine hydrate.

Workup

  1. customdescribed in Preparation 15'
  2. customprepared

Sources & evidence

ORD record
ord-a7389c0a361647cf940b648c4d526c57
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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