反应详情

A mixture of 3-(2-bromoacetyl)pyrazole-3-carboxylic acid ethyl ester (7.00 g), thionicotinamide (3.51 g), and ethanol (50 ml) was refluxed for 16 hours. The resulting mixture was poured into 400 ml of water, and neutralized with 10 g of sodium bicarbonate. Filtration afforded 5.82 g of 3-ethoxycarbonyl-5-(2-(3-pyridinyl)thiazol-4-yl)pyrazole as yellow solids, mp 105°-107° C. NMR: 1.43 (t, 3H), 4.44 (q, 2H), 7.26 (s, 1H, 5-thiazolyl H), 7.70 (s, 1H, 4-pyrazolyl H), 7.42, 8.30, 8.73, 9.27 (4 m, 4H, pyridinyl H's).

1. temperaturewas refluxed for 16 hours
2. filtrationFiltration