홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1299695
노트
인쇄 미리보기

반응식

HRID 1299695 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COCCOCCOC.[K+].c1ccc(P(c2ccccc2)c2ccccc2P(c2ccccc2)c2ccccc2)cc1>FC(F)(F)c1ccc(N2CCOCC2)cc1
참가 물질반응 조건후처리출처 및 근거반응 노트

참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 4

HCID 23665647Potassium tert-butoxide시약HCID 4983791,2-Bis(diphenylphosphino)benzene촉매HCID 178440864HCID 178440864, 화합물촉매HCID 8150Diglyme용매5회

반응 조건

온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-23bfac48e52a4aa791d3fa82df4d7d75
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI
10.1021/jacs.6c05959
원본 링크
출처 보기

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건후처리출처 및 근거반응 노트