(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester → (2S)-2-(azepane-1-carbonylamino)-4-methylpentanoic acid

HRID 129989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129989
C([O:8][C:9](=[O:25])[C@H:10]([CH2:21][CH:22]([CH3:24])[CH3:23])[NH:11][C:12]([N:14]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1.[H][H]>CO.[Pd]>[N:14]1([C:12]([NH:11][C@H:10]([C:9]([OH:25])=[O:8])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:13])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Komponenten

5

Edukt 2

HCID 10593708(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 7530182(2S)-2-(azepane-1-carbonylamino)-4-methylpentanoic acidAusbeute 92,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound obtained in (1) (1.75 g) was dissolved in methanol (30 ml). 10% Pd-C (0.30 g) was added and the mixture was stirred vigorously at room temperature under atmospheric pressure of hydrogen for 1.5 h. The catalyst was filtered off and the filtrate was concentrated to give the product (1.2 g) as a colorless foam.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-889e91f1dc6047989ae98c198219eeb7
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05470833

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