Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1300459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1300459
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].CC(C)(C)c1cc(P(c2cc(C(C)(C)C)cc(C(C)(C)C)c2)C2CCCC2)cc(C(C)(C)C)c1.COCCOCCOC.O=C1[CH](=Cc2ccccc2)->[Pd]2(<-[CH]1=Cc1ccccc1)<-[CH](=Cc1ccccc1)C(=O)[CH]->2=Cc1ccccc1.[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Komponenten

9

Edukt 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 0 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23665647Potassium tert-butoxideReagenzHCID 124081666HCID 124081666, VerbindungKatalysatorHCID 178516675HCID 178516675, VerbindungKatalysatorHCID 8150DiglymeLösungsmittel5×

Reaktionsbedingungen

Temperatur
30 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-bc30526c562f4dcc8b6bafcdb1a98e44
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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