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HRID1301674

反应详情

EQUATION

反应方程式

HRID 1301674 的结构方程式

REACTANTS

反应物

2
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：FC(F)(F)c1ccc(Br)cc1
HCID67872

Benzene, 1-bromo-4-(trifluoromethyl)-

C7H4BrF3

PRODUCTS

生成物

3
结构：Cn1c(=O)c2c(ncn2C)n(C)c1=O
HCID2519

Caffeine

C8H10N4O2

结构：FC(F)(F)c1ccc(N2CCOCC2)cc1
HCID10933310

Morpholine, 4-[4-(trifluoromethyl)phenyl]-

C11H12F3NO

收率 0%
结构：FC(F)(F)c1cccc(N2CCOCC2)c1
HCID15420299

4-[3-(Trifluoromethyl)phenyl]morpholine

C11H12F3NO

收率 0%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：C[Si](C)(C)[O-].[Li+]
试剂HCID74821

Silanol, trimethyl-, lithium derivative

C3H9LiOSi

结构：c1ccc(-c2nn(-c3ccccc3)c(-c3ccccc3)c2-n2nccc2P(C2CCCCC2)C2CCCCC2)cc1
催化剂HCID53430914

5-(Dicyclohexylphosphanyl)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole

C36H39N4P

结构：O=C(O[Pd]OC(=O)C(F)(F)F)C(F)(F)F
催化剂HCID178526102

未命名化合物

结构：COCCOCCOC
溶剂HCID8150

Diethylene glycol dimethyl ether

C6H14O3

CONDITIONS

反应条件

温度
60 °C

WORKUP

后处理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · 保留 liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.