Acetic Acid → HCID 18458085, compound

HRID 130295Notes

Reaction equation

HRID 130295 reaction equation
C(C1[S:7][C:6]([C:8](=[O:19])[CH2:9][C:10](=[O:18])[C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])=[CH:5][CH:4]=1)#N.S(=O)(=O)(O)O.[C:25]([OH:28])(=[O:27])[CH3:26]>O>[C:25]([C:26]1[S:7][C:6]([C:8](=[O:19])[CH2:9][C:10](=[O:18])[C:11]([F:17])([F:16])[C:12]([F:13])([F:14])[F:15])=[CH:5][CH:4]=1)([OH:28])=[O:27]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 184580865-(4,4,5,5,5-Pentafluoro-3-oxopentanoyl)thiophene-2-carbonitrile

Product 1

HCID 18458085HCID 18458085, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1-(5-cyano-2-thienyl)-4,4,5,5,5-pentafluoro-1,3-pentanedione (0.78 g), sulfuric acid (9 ml) and acetic acid (10 ml) was refluxed for 2 hours. The cooled mixture was poured into 100 ml of water. The precipitation was filtered and washed with water. 1H NMR (CDCl3): 6.53 (s, 1 H); 7.57 (d, 1H, J=4.1 Hz); 7.78 (d, 1H, J=4.1 Hz).

Workup

  1. temperaturewas refluxed for 2 hours
  2. customThe precipitation
  3. filtrationwas filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-69ceee4e75614818a57ad74fb53c4c15
Source dataset
uspto-grants-2008_06
Patent number
US07381567B2

Reaction notes

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