反应详情

A mixture of 200 mg (0.97 mmol) of the benzoxazinone prepared in Example 4 and 119 mg (0.97 mmol) of p-anisidine in 5 ml of xylene was refluxed for 4 hours. The solvent was removed and the target compound purified by flash chromatography on silica gel (loaded with CH2Cl2 and eluted with 40% EtOAc in hexane) to obtain 120 mg of 5,7-dimethoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone (40% yield) as a white solid.

1. temperaturewas refluxed for 4 hours
2. customThe solvent was removed
3. customthe target compound purified by flash chromatography on silica gel (loaded with CH2Cl2 and eluted with 40% EtOAc in hexane)