HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → 4-(2-Benzenesulfonylamino-thiazol-4-yl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Methyl 4-(2-aminothiazol-4-yl)benzoate | HCID 2060012 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-Benzenesulfonylamino-thiazol-4-yl)-benzoic acid methyl ester | HCID 86607373 | — |
Reaction Steps
A mixture of 4-(2-amino-thiazol-4-yl)-benzoic acid methyl ester (1.17 g, 5 mmol), benzenesulfonyl chloride (1.06 g, 6 mmol) and 4-dimethylaminopyridine (2.20 g, 18 mmol) in CH2Cl2 (50 mL) was stirred at room temp for 18 h. A white solid was provided as 4-(2-benzenesulfonylamino-thiazol-4-yl)-benzoic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07381736B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-9b5dde3f6bc346c7b1696a5757c9d2cb |
| Source note | uspto-grants-2008_06 |