反应详情

Potassium fluoride (99%) (12 g, 216 mmol) was added to a solution of 2-fluoro-benzenesulfonyl chloride (10 g, 51 mmol) in 1, 4 dioxane (35 mL). The reaction mixture was refluxed for 24 hours, then cooled to room temperature and poured into ice water (200 mL). The ice water was extracted with chloroform (3×50 mL). The combined chloroform layers were dried (MgSO4), filtered, and concentrated to afford 2-fluoro-benzenesulfonyl fluoride (2a) as a colorless oil 6.7 g (74%). (M+H)+=177

1. temperatureThe reaction mixture was refluxed for 24 hours
2. extractionThe ice water was extracted with chloroform (3×50 mL)
3. dry with materialThe combined chloroform layers were dried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated