Thionyl Chloride → HCID 55207327, compound

HRID 130419Notes

Reaction equation

HRID 130419 reaction equation
[Na+].[Cl:2][C:3]1[N:8]=[CH:7][C:6]([S:9]([O-:12])(=O)=[O:10])=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O>>[ClH:2].[Cl:2][C:3]1[N:8]=[CH:7][C:6]([S:9]([Cl:15])(=[O:12])=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 87730756HCID 87730756, compound

Product 1

HCID 55207327HCID 55207327, compound

Conditions

Temperature
70 °C

Procedure

A mixture of the product of Step 1 (430 mg, 2 mmol) in thionyl chloride (3 ml) and N,N-dimethylformide (2 drops) was heated at 70° C. for 3 hours. After cooling to room temperature the solvent was evaporated and the residue co-evaporated with toluene (×2) to give the title compound (D32) which was used directly in Step 1 of Example 272. 1H-NMR (CDCl3) δ 7.61 (1H, m), 8.25 (1H, m), 9.03 (1H, m).

Workup

  1. temperatureAfter cooling to room temperature the solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-0f096c22a04e457ebf3bf03f01e59636
Source dataset
uspto-grants-2008_06
Patent number
US07381728B2

Reaction notes

Loading…