2-[6-(4-Iodo-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxy-N-pyridin-3-yl-benzamide → HCID 58630250, compound

HRID 130494Notes

Reaction equation

HRID 130494 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][C:11]3[C:14]([C:34]([F:37])([F:36])[F:35])=[N:15][N:16]([C:17]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:18]=4[C:19]([NH:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)=[O:20])[C:10]=3[C:9]2=[O:38])=[CH:4][CH:3]=1.[H][H]>[Pd].C(O)C>[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:17]([N:16]2[C:10]3[C:9](=[O:38])[N:8]([C:5]4[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=4)[CH2:13][CH2:12][C:11]=3[C:14]([C:34]([F:36])([F:35])[F:37])=[N:15]2)=[C:18]([CH:28]=1)[C:19]([NH:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)=[O:20]

Participants

5

Reactant 2

HCID 586302342-[6-(4-Iodo-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxy-N-pyridin-3-yl-benzamideHCID 178418361HCID 178418361, compound

Product 1

HCID 58630250HCID 58630250, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-[6-(4-Iodo-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxy-N-pyridin-3-yl-benzamide (15 mg, 0.023 mmol) was combined with 5% palladium on carbon and stirred in ethanol under 1 atmosphere of hydrogen for 12 h. The reaction mixture was filtered through diatomaceous earth and the solvent evaporated to give the title compound (11 mg, 95%) as a colorless solid. MS (ES+) 508.0 (M+H)+(100%).

Workup

  1. filtrationThe reaction mixture was filtered through diatomaceous earth
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-24386bfe1d524752912c398204db8879
Source dataset
uspto-grants-2008_06
Patent number
US07381732B2

Reaction notes

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