Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1305037Notes

Reaction equation

HRID 1305037 reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].COC(=O)C(C)=[CH2]->[Ni](<-[CH2]=C(C)C(=O)OC)[CH]1N(c2c(C(C)C)cccc2C(C)C)CCN1c1c(C(C)C)cccc1C(C)C.COCCOCCOC.[K+].c1ccc(P(c2ccccc2)[c]23->[Fe+2]456789%10(<-[cH]([cH]->4[cH-]->52)[cH]->63)<-[cH]2[cH]->7[cH-]->8[c]->9(P(c3ccccc3)c3ccccc3)[cH]->%102)cc1>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

9

Reactant 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 16.57%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 4

HCID 23665647Potassium tert-butoxideReagentHCID 178420530HCID 178420530, compoundCatalystHCID 178500470HCID 178500470, compoundCatalystHCID 8150DiglymeSolvent5×

Conditions

Temperature
60 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-68c57f48c6a04d498c1fe490ee073ec9
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

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