HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 130581Generated: October 30, 2026
Hydrochloric Acid → 1,1-Cyclohexanediacetic acid monoamide
https://huagongshe.com/reaction/130581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Azaspiro(5.5)undecane-2,4-dione | HCID 14324 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Product | 1,1-Cyclohexanediacetic acid monoamide | HCID 665664 | 64.7% |
Reaction Steps
9 g of 2,4-dioxo-3-azaspiro[5,5]undecane and 30 g of 10% NaOH are placed in a 250 ml flask equipped with mechanical agitator, thermometer and condenser. The mixture is heated under reflux for 1 hour, cooled to 25° C. and acidified with 36% HCl to pH 5. The precipitate formed is filtered off, washed with water and dried under vacuum. 6.4 g of cyclohexanediacetic acid monoamide are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07381823B2 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-9471e4e251454c4a8102280b56656837 |
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| Source note | uspto-grants-2008_06 |
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