反应详情

温度

25 °C

9 g of 2,4-dioxo-3-azaspiro[5,5]undecane and 30 g of 10% NaOH are placed in a 250 ml flask equipped with mechanical agitator, thermometer and condenser. The mixture is heated under reflux for 1 hour, cooled to 25° C. and acidified with 36% HCl to pH 5. The precipitate formed is filtered off, washed with water and dried under vacuum. 6.4 g of cyclohexanediacetic acid monoamide are obtained.

1. customequipped with mechanical agitator
2. temperatureThe mixture is heated
3. temperatureunder reflux for 1 hour
4. customThe precipitate formed
5. filtrationis filtered off
6. washwashed with water
7. customdried under vacuum