1-(4-Fluorophenyl)-5-iodo-6-methylindazole → (1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)-propan-2-amine

HRID 13071Notes

Reaction equation

HRID 13071 reaction equation
[Cl-].[OH:2][C@H:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=1)[C@@H:4]([NH3+:6])[CH3:5].[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27](I)=[C:28]([CH3:31])[CH:29]=3)[CH:24]=[N:23]2)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([O:2][C@H:3]([C:7]4[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=4)[C@@H:4]([NH2:6])[CH3:5])=[C:28]([CH3:31])[CH:29]=3)[CH:24]=[N:23]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 593399141-(4-Fluorophenyl)-5-iodo-6-methylindazoleHCID 66812892(1R,2S)-1-hydroxy-1-(3-methoxyphenyl)propan-2-aminium chloride

Product 1

HCID 59339755(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)-propan-2-amine

Procedure

Prepared as described in Example 1 from (1R,2S)-1-hydroxy-1-(3-methoxyphenyl)propan-2-aminium chloride (185 mg, 0.85 mmol) and 1-(4-fluorophenyl)-5-iodo-6-methylindazole (300 mg, 0.85 mmol). Yield 224 mg (65%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d8776488ddd644b8b4cc14850be762bd
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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