HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluorophenyl)-5-iodo-6-methylindazole → (1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)-propan-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluorophenyl)-5-iodo-6-methylindazole | HCID 59339914 | — |
| Reactant | (1R,2S)-1-hydroxy-1-(3-methoxyphenyl)propan-2-aminium chloride | HCID 66812892 | — |
| Product | (1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)-propan-2-amine | HCID 59339755 | — |
Reaction Steps
Prepared as described in Example 1 from (1R,2S)-1-hydroxy-1-(3-methoxyphenyl)propan-2-aminium chloride (185 mg, 0.85 mmol) and 1-(4-fluorophenyl)-5-iodo-6-methylindazole (300 mg, 0.85 mmol). Yield 224 mg (65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d8776488ddd644b8b4cc14850be762bd |
| Source note | uspto-grants-2010_06 |