(2RS,3RS)-3-amino-1-phenoxy-butan-2-ol → (2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine

HRID 13078Notes

Reaction equation

HRID 13078 reaction equation
[NH2:1][CH:2]([CH3:13])[CH:3]([OH:12])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26](I)=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26]([O:12][CH:3]([CH2:4][O:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=4)[CH:2]([NH2:1])[CH3:13])=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 15105310(2RS,3RS)-3-amino-1-phenoxy-butan-2-olHCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazole

Product 1

HCID 66812100(2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine

Procedure

Prepared as described in Example 1 from (2RS,3SR)-3-amino-1-phenoxy-butan-2-ol (319 mg, 1.75 mmol), and 1-(4-fluorophenyl)-5-iodoindazole (710 mg, 2.10 mmol). Yield 244 mg (36%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b4d9d8e75f5e40e998bb31e81d1abe76
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

Loading…