HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 131053Generated: October 25, 2026
Triethylamine → Tert-butyl 2-(4-nitrophenylamino)propionate
https://huagongshe.com/reaction/131053
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | L-Alanine 1,1-dimethylethyl ester | HCID 89016 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tert-butyl 2-(4-nitrophenylamino)propionate | HCID 58596136 | 33.6% |
Reaction Steps
388 mg of 4-fluoronitrobenzene, 500 mg of L-alanine tert-butyl ester and 0.9 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone. The reaction medium was heated at 70° C. for 20 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 246 mg of tert-butyl 2-(4-nitrophenylamino)propionate (10) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07384432B2 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-79adefcb38fd4457bda61c8c9d8bb863 |
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| Source note | uspto-grants-2008_06 |
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