Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1311600Notes

Reaction equation

HRID 1311600 reaction equation
C1COCCN1.FC(F)(F)c1ccc(I)cc1>CC(C)(C)[O-].CC(C)(C)[P]1(C(C)(C)C)[c]23->[Fe+2]456789%10(<-[cH]([cH]->4[cH-]->52)[cH]->63)<-[cH]2[cH]->7[cH-]->8[c]->9([P](C(C)(C)C)(C(C)(C)C)->[Pd]<-1([Cl])[Cl])[cH]->%102.CS(C)=O.[Cu][I].[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

9

Reactant 2

HCID 8083MorpholineHCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 4

HCID 23665647Potassium tert-butoxideReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 178454856HCID 178454856, compoundCatalystHCID 679Dimethyl SulfoxideSolvent5×

Conditions

Temperature
80 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-6a6b7eae57004dd79d7e5a9db115959d
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

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