Water → HCID 68467367, compound

HRID 131207Notes

Reaction equation

HRID 131207 reaction equation
[CH2:1]([O:4][C:5](=[O:35])[C:6]1[CH:11]=[CH:10][C:9]([N:12]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[C:8]([N+]([O-])=O)[CH:7]=1)[CH:2]=[CH2:3].Cl[Sn]Cl.O.C[N:41](C=O)C>>[CH2:1]([O:4][C:5](=[O:35])[C:6]1[CH:11]=[CH:10][C:9]([N:12]([C:25]([O:27][C:28]([CH3:29])([CH3:31])[CH3:30])=[O:26])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:23])([F:22])[F:24])=[CH:16][CH:15]=2)=[CH:8][C:7]=1[NH2:41])[CH:2]=[CH2:3]

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 24479Stannous ChlorideHCID 68463081HCID 68463081, compound

Product 1

HCID 68467367HCID 68467367, compound

Procedure

2 g of 4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-nitro-benzoic acid allyl ester (4.0 mmol) were dissolved in 20 ml DMF. 2.8 g SnCl2×2 H2O (12 mmol) are added and the reaction stirred at room temperature for 16 h. The crude was filtered over Kieselgel and the solvent evaporated. MS(ISP): 467.3 (M+H)+.

Workup

  1. filtrationThe crude was filtered over Kieselgel
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-482ce540930f4b278bd215ad5369c7f4
Source dataset
uspto-grants-2008_06
Patent number
US07384945B2

Reaction notes

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