反应详情

温度

95 °C

To N-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-ylthio)-1-phenylpropan-2-yl)-2-(trimethylsilyl)ethanesulfonamide (103a, 0.042 g, 0.08 mmol) in DMF (2 mL) cesium fluoride (8.60 μL, 0.23 mmol) was added and the mixture was stirred at 95° C. Stirring was continued at that temperature O/N. Cooled at rt the solvent was removed and the mixture was partitioned between EtOAc/water the organic phase was than purified with HPLC The relevant fractions were collected freezdried to give 24 mg of product (84% yield) which was analysed by LC/MS.

1. stirringStirring
2. temperatureCooled at rt the solvent
3. customwas removed
4. customthe mixture was partitioned between EtOAc/water the organic phase
5. customthan purified with HPLC The relevant fractions
6. customwere collected freezdried