Water → 1-(4-Fluorophenyl)-1H-indazole-5-thiol

HRID 13124Notes

Reaction equation

HRID 13124 reaction equation
C(=O)([S:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[N:13]=[CH:12]2)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].O>CO>[F:24][C:21]1[CH:20]=[CH:19][C:18]([N:14]2[C:15]3[C:11](=[CH:10][C:9]([SH:8])=[CH:17][CH:16]=3)[CH:12]=[N:13]2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 59339848S-1-(4-Fluorophenyl)-1H-indazol-5-yl benzothioate

Product 1

HCID 593397121-(4-Fluorophenyl)-1H-indazole-5-thiol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To S-1-(4-fluorophenyl)-1H-indazol-5-yl benzothioate (0.046 g, 0.13 mmol) in methanol (3 mL), potassium carbonate (0.011 mL, 0.20 mmol) was added and the mixture was stirred at r.t. for 2 h. water was than added, 1N HCl (2 ml) and extracted with EtOAc (2*20 ml), dried, evaporated and then purified on HPLC. The relevant fractions were collected freeze dried and analysed by LC/MS.

Workup

  1. additionthan added
  2. extraction1N HCl (2 ml) and extracted with EtOAc (2*20 ml)
  3. customdried
  4. customevaporated
  5. custompurified on HPLC
  6. customThe relevant fractions were collected freeze
  7. customdried

Sources & evidence

ORD record
ord-486757b1d56d4f24a7c4fda7cad5e445
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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