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HRID1313385

反应详情

EQUATION

反应方程式

HRID 1313385 的结构方程式

REACTANTS

反应物

2
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：FC(F)(F)c1ccc(Br)cc1
HCID67872

Benzene, 1-bromo-4-(trifluoromethyl)-

C7H4BrF3

PRODUCTS

生成物

3
结构：Cn1c(=O)c2c(ncn2C)n(C)c1=O
HCID2519

Caffeine

C8H10N4O2

结构：FC(F)(F)c1ccc(N2CCOCC2)cc1
HCID10933310

Morpholine, 4-[4-(trifluoromethyl)phenyl]-

C11H12F3NO

收率 7.33%
结构：FC(F)(F)c1cccc(N2CCOCC2)c1
HCID15420299

4-[3-(Trifluoromethyl)phenyl]morpholine

C11H12F3NO

收率 0%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CC(C)(C)[O-].[K+]
试剂HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

结构：CCCCc1c(F)c(F)c(-c2c(C(C)C)cc(C(C)C)c(-c3cccc(OC)c3P(C34CC5CC(CC(C5)C3)C4)C34CC5CC(CC(C5)C3)C4)c2C(C)C)c(F)c1F
催化剂HCID121237782

Bis(1-adamantyl)-[2-[3-(4-butyl-2,3,5,6-tetrafluorophenyl)-2,4,6-tri(propan-2-yl)phenyl]-6-methoxyphenyl]phosphane

C52H67F4OP

结构：COCCOCCOC
溶剂HCID8150

Diethylene glycol dimethyl ether

C6H14O3

CONDITIONS

反应条件

温度
60 °C

WORKUP

后处理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · 保留 liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.