Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1314265Notes

Reaction equation

HRID 1314265 reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].CC(C)P(C(C)C)[c]12->[Fe+2]3456789(<-[cH]([cH]->3[cH-]->41)[cH]->52)<-[cH]1[cH]->6[cH-]->7[c]->8(P(C2C3CC4CC(C3)CC2C4)C2C3CC4CC(C3)CC2C4)[cH]->91.COCCOCCOC.O=S1C(c2ccccc2)=[C]2(c3ccccc3)->[Ni]3(<-[CH]4=CCC[CH]->3=CCC4)<-[C]1(c1ccccc1)=C2c1ccccc1.[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

9

Reactant 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 2.72%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 4

HCID 23665647Potassium tert-butoxideReagentHCID 178460671HCID 178460671, compoundCatalystHCID 178527110HCID 178527110, compoundCatalystHCID 8150DiglymeSolvent5×

Conditions

Temperature
60 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-09b19ae1375b439588d731c0d9563486
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

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