HCID 135543774, compound → HCID 136384193, compound

HRID 131432Notes

Reaction equation

[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].F[C:10]1[CH:11]=[CH:12][C:13]2[NH:19][C:18]3[CH:20]=[CH:21][C:22]([C:24]([F:27])([F:26])[F:25])=[CH:23][C:17]=3[C:16]([N:28]3[CH2:33][CH2:32][N:31]([CH3:34])[C@@H:30]([CH2:35][CH2:36][O:37][CH3:38])[CH2:29]3)=[N:15][C:14]=2[CH:39]=1.[Cl:40]C1C=CC2NC3C=CC(C(F)(F)F)=CC=3C(N3CCN[C@@H](CCOC)C3)=NC=2C=1>>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:40][C:10]1[CH:11]=[CH:12][C:13]2[NH:19][C:18]3[CH:20]=[CH:21][C:22]([C:24]([F:27])([F:26])[F:25])=[CH:23][C:17]=3[C:16]([N:28]3[CH2:33][CH2:32][N:31]([CH3:34])[C@@H:30]([CH2:35][CH2:36][O:37][CH3:38])[CH2:29]3)=[N:15][C:14]=2[CH:39]=1

Participants

Reactant 2

HCID 135543774HCID 135543774, compound

HCID 136388582HCID 136388582, compound

Product 1

HCID 136384193HCID 136384193, compoundYield 100%

Procedure

Using a method similar to Example (S)-8-fluoro-2-trifluoromethyl-11-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine succinate, using (S)-8-chloro-2-trifluoromethyl-11-[3-(2-methoxy-ethyl)-piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine (0.051 g, 0.12 mmol) to give 0.054 g (100% yield) of the free base as a yellow oil which is converted to the succinate salt as described previously: Mass Spectrum (m/e): 454(M+1).

Sources & evidence

ORD record: ord-7de3ff5d77e94d15bee512ec1bcb5dd1
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384934B2

Reaction notes

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