HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-6,7-Difluoro-10-[3-(2-methoxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-6,7-Difluoro-10-[3-(2-methoxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene | HCID 135434034 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-6,7-Difluoro-10-[3-(2-methoxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride | HCID 136355246 | 99% |
Reaction Steps
Dissolve (S)-6,7-difluoro-10-[3-(2-methoxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene (730 mg, 1.86 mmol) in ethyl acetate. Add 2.5 equivalents of hydrogen chloride in ethanol. After 3 hours filter the precipitate, wash with ethyl acetate and dry under vacuum to give the title compound (856 mg, 99%): Mass Spectrum (ESMS) 393 (M+1); 391 (M−1), mp 198-202° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384934B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-7034f21f99704b53aa20cfe9a9a44522 |
| Source note | uspto-grants-2008_06 |