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HRID131453

反应详情

EQUATION

反应方程式

HRID 131453 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COCC[C@H]1CN(C2=Nc3cc(F)c(F)cc3Nc3sc(C)cc32)CCN1
HCID135434034

未命名化合物

PRODUCTS

生成物

1
结构：COCC[C@H]1CN(C2=Nc3cc(F)c(F)cc3Nc3sc(C)cc32)CCN1.Cl.Cl
HCID136355246

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Dissolve (S)-6,7-difluoro-10-[3-(2-methoxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene (730 mg, 1.86 mmol) in ethyl acetate. Add 2.5 equivalents of hydrogen chloride in ethanol. After 3 hours filter the precipitate, wash with ethyl acetate and dry under vacuum to give the title compound (856 mg, 99%): Mass Spectrum (ESMS) 393 (M+1); 391 (M−1), mp 198-202° C. (dec).

WORKUP

后处理

  1. filtrationAfter 3 hours filter the precipitate
  2. washwash with ethyl acetate
  3. customdry under vacuum