(S)-2-(2-Methoxyethyl)piperazine → (S)-10-[3-(2-Methoxyethyl)piperazin-1-yl]-2-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene

HRID 131485Notes

Reaction equation

HRID 131485 reaction equation
Cl.[CH3:2][C:3]1[S:12][C:11]2[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[N:7]=[C:6]([NH2:17])[C:5]=2[N:4]=1.[CH3:18][O:19][CH2:20][CH2:21][C@H:22]1[CH2:27]N[CH2:25][CH2:24][NH:23]1>>[CH3:18][O:19][CH2:20][CH2:21][C@@H:22]1[NH:23][CH2:24][CH2:25][N:17]([C:6]2[C:5]3[N:4]=[C:3]([CH3:2])[S:12][C:11]=3[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[N:7]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 55287560(S)-2-(2-Methoxyethyl)piperazineHCID 1357977452-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine hydrochloride

Product 1

HCID 135464220(S)-10-[3-(2-Methoxyethyl)piperazin-1-yl]-2-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene

Procedure

In a manner such as that described in Example 300, combine 2-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine hydrochloride (0.437 g, 1.64 mmol) and (S)-2-(2-methoxyethyl)piperazine (0.474 g, 3.29 mmol) to obtain the title compound: mass spectrum (APCI): m/z=358.0 (M+1).

Sources & evidence

ORD record
ord-d03035609b3a4f65bcaefcbfe3bfc5ab
Source dataset
uspto-grants-2008_06
Patent number
US07384934B2

Reaction notes

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