(S)-2-(2-ethoxyethyl)piperazine → (S)-10-[3-(2-Ethoxyethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene
Reaction equation
[CH3:1][C:2]1[S:11][C:10]2[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=[C:5]([NH2:16])[C:4]=2[N:3]=1.[CH2:17]([O:19][CH2:20][CH2:21][C@H:22]1[CH2:27]N[CH2:25][CH2:24][NH:23]1)[CH3:18]>>[CH2:17]([O:19][CH2:20][CH2:21][C@@H:22]1[NH:23][CH2:24][CH2:25][N:16]([C:5]2[C:4]3[N:3]=[C:2]([CH3:1])[S:11][C:10]=3[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=2)[CH2:27]1)[CH3:18]Participants
3
Procedure
In a manner similar to that described in Example 300, combine 2-methyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine (0.534 g, 2.01 mmol) and (S)-2-(2-ethoxyethyl)piperazine (0.635 g, 4.01 mmol) to obtain the title compound: Exact Mass, Calc: 372.1858; Found: 372.1867.
Sources & evidence
- ORD record
- ord-4547b28dff204ed9bc849e2235959cfa
- Source dataset
- uspto-grants-2008_06
- Patent number
- US07384934B2
Reaction notes
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