(S)-2-(Piperazin-2-yl)ethanol → (S)-2-[4-(2-Isopropyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-yl)-piperazin-2-yl]ethanol
Reaction equation
Cl.[CH:2]([C:5]1[S:14][C:13]2[NH:12][C:11]3[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=3[N:9]=[C:8]([NH2:19])[C:7]=2[N:6]=1)([CH3:4])[CH3:3].[NH:20]1[CH2:25][CH2:24]N[CH2:22][C@@H:21]1[CH2:26][CH2:27][OH:28]>>[CH:2]([C:5]1[S:14][C:13]2[NH:12][C:11]3[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=3[N:9]=[C:8]([N:19]3[CH2:24][CH2:25][NH:20][C@@H:21]([CH2:26][CH2:27][OH:28])[CH2:22]3)[C:7]=2[N:6]=1)([CH3:4])[CH3:3]Participants
3
Procedure
In a manner such as that described in Example 300, combine 2-isopropyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine hydrochloride (0.558 g, 1.89 mmol) and (S)-2-piperazin-2-yl-ethanol (0.493 g, 3.79 mmol) to obtain the title compound: mass spectrum (APCI): m/z=372.4 (M+1).
Sources & evidence
- ORD record
- ord-be7519a5d7ad4aed8eb136ef194b0feb
- Source dataset
- uspto-grants-2008_06
- Patent number
- US07384934B2
Reaction notes
Loading…